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Nicotine is an addictive substance found most commonly in tobacco and tobacco products including cigarettes, cigars, chewing tobacco, e-cigarette liquid, pipe tobacco, snus, snuff, and nicotine medications such as nicotine gum. Withdrawal is the body’s reaction to not having the nicotine it had become accustomed to.
Using chewing tobacco increases the risk of fatal coronary heart disease and stroke. [25] [26] In 2010 more than 200 000 people died from coronary heart disease due to smokeless tobacco use. [27] Use of chewing tobacco also seems to greatly raise the risk of non-fatal ischaemic heart disease among users in Asia, although not in Europe. [25]
While cigarettes are the most commonly used tobacco product, all forms of tobacco use—including smokeless tobacco and e-cigarette use—can cause dependence. [3] [10] Nicotine dependence is a serious public health problem because it leads to continued tobacco use and the associated negative health effects. Tobacco use is one of the leading ...
The LD 50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 0.5–1.0 mg/kg can be a lethal dosage for adult humans, and 0.1 mg/kg for children. [19] [20] However the widely used human LD 50 estimate of 0.5–1.0 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses; the 2013 review suggests that the lower limit causing fatal ...
Nicotine replacement therapy (NRT) is a medically approved way to treat people with tobacco use disorder by taking nicotine through means other than tobacco. [6] It is used to help with quitting smoking or stopping chewing tobacco. [1] [7] It increases the chance of quitting tobacco smoking by about 55%. [8]
The Government of Maharashtra has banned the sale of manufactured chewing tobacco, including Mawa in July 2015. [11] [12] Mawa is prohibited in Pakistan. [13] [14] The Greater Chennai Police confiscated over 30 kg of banned tobacco, including 22 kg of gutkha and 9 kg of Mawa in February 2023. [15]
Nicotine use for tobacco cessation has few contraindications. [71] It is not known whether nicotine replacement therapy is effective for smoking cessation in adolescents, as of 2014. [72] It is therefore not recommended to adolescents. [73] It is not safe to use nicotine during pregnancy or breastfeeding, although it is safer than smoking.
It differs from moist snuff or chewing tobacco in that it is made from steam-cured tobacco leaves, rather than fire-cured ones, and its health effects are markedly different, with epidemiological studies showing lower rates of cancer and other tobacco-related health problems than cigarettes, American "chewing tobacco", Indian gutka or African ...