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Brain abscess (or cerebral abscess) is an abscess within the brain tissue caused by inflammation and collection of infected material coming from local (ear infection, dental abscess, infection of paranasal sinuses, infection of the mastoid air cells of the temporal bone, epidural abscess) or remote (lung, heart, kidney etc.) infectious sources.
Amoebic brain abscess is an affliction caused by the anaerobic parasitic protist Entamoeba histolytica.It is extremely rare; the first case being reported in 1849. [2] Brain abscesses resulting from Entamoeba histolytica are difficult to diagnose and very few case reports suggest complete recovery even after the administration of appropriate treatment regimen.
Cladophialophora bantiana (C. bantiana) is a melanin producing mold known to cause brain abscesses in humans. [1] It is one of the most common causes of systemic phaeohyphomycosis in mammals. [2] Cladophialophora bantiana is a member of the ascomycota and has been isolated from soil samples from around the world. [3]
The cyst wall is formed by proliferating capillaries, inflammatory cells, and gliosis (proliferating glial cells) in the case of brain and proliferating fibroblasts in the case of abscess cavities. Brain cells have a large amount of digestive enzymes (hydrolases). These enzymes cause the neural tissue to become soft and liquefy.
Infections of the central nervous system (CNS) consist of infections primarily of the brain and spinal cord. They include mostly viral infections , less commonly bacterial infections , fungal infections , prion diseases and protozoan infections .
The final structure of the abscess is an abscess wall, or capsule, that is formed by the adjacent healthy cells in an attempt to keep the pus from infecting neighboring structures. However, such encapsulation tends to prevent immune cells from attacking bacteria in the pus, or from reaching the causative organism or foreign object.
Further, a thrombophlebitis may develop in the bridging veins that cross the subdural space, resulting in venous occlusion and infarction of the brain. With treatment, including surgical drainage, resolution of the empyema occurs from the dural side, and, if it is complete, a thickened dura may be the only residual finding.
Cerebral edema is commonly seen in a variety of brain injuries including ischemic stroke, subarachnoid hemorrhage, traumatic brain injury, subdural, epidural, or intracerebral hematoma, hydrocephalus, brain cancer, brain infections, low blood sodium levels, high altitude, and acute liver failure.