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Benfotiamine has been studied in laboratory models of diabetic retinopathy, neuropathy, and nephropathy. [10] A 2021 review of its use for diabetic polyneuropathy described two clinical trials which showed improvements in neuropathic pain and neuropathic symptoms scores, the latter of which showed a dose-response effect. [4]
Alpha lipoic acid (ALA) with benfotiamine is a proposed pathogenic treatment for painful diabetic neuropathy only. [119] The results of two systematic reviews state that oral ALA produced no clinically significant benefit, intravenous ALA administered over three weeks may improve symptoms and that long-term treatment has not been investigated ...
A 2007 review of studies found that injected administration of alpha lipoic acid (ALA) was found to reduce the various symptoms of peripheral diabetic neuropathy. [73]
In simple terms, sciatica is a pain that radiates along the sciatic nerve, the longest nerve in the human body. It runs from the lower back down through the buttocks and into the legs and feet.
Recent evidence suggests that acupuncture can help relieve the pain caused by sciatica, a common condition in which the sciatic nerve becomes compressed. Acupuncture can help relieve sciatica pain ...
Lipoic acid (LA), also known as α-lipoic acid, alpha-lipoic acid (ALA) and thioctic acid, is an organosulfur compound derived from caprylic acid (octanoic acid). [3] ALA, which is made in animals normally, is essential for aerobic metabolism. It is also available as a dietary supplement or pharmaceutical drug in some countries.