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The use of trapezoidal rule in AUC calculation was known in literature by no later than 1975, in J.G. Wagner's Fundamentals of Clinical Pharmacokinetics. A 1977 article compares the "classical" trapezoidal method to a number of methods that take into account the typical shape of the concentration plot, caused by first-order kinetics. [8]
Aliquot of a sample, in chemistry and other sciences, a precise portion of a sample or total amount of a liquid (e.g. precisely 25 mL of water taken from 250 mL); Aliquot in pharmaceutics, a method of measuring ingredients below the sensitivity of a scale by proportional dilution with inactive known ingredients
Hook's-SupeRx acquired the New England–based Brooks Pharmacy chain in 1988. [3] Hooks-SupeRx stores traded under three different names – Hook's Drug and SupeRx in the Midwest and Brooks Pharmacy in New England. Hook's-SupeRx was acquired by Revco in 1994. [1] Revco was subsequently acquired by CVS in 1997. Many former Hook's locations are ...
The procedure is to take the child's weight in pounds, divide by 150 lb, and multiply the fractional result by the adult dose to find the equivalent child dosage.For example, if an adult dose of medication calls for 30 mg and the child weighs 30 lb, divide the weight by 150 (30/150) to obtain 1/5 and multiply 1/5 times 30 mg to get 6 mg.
Pharmaceutics is the discipline of pharmacy that deals with the process of turning a new chemical entity (NCE) or an existing drug into a medication to be used safely and effectively by patients. [1] The patients could be either humans or animals. Pharmaceutics helps relate the formulation of drugs to their delivery and disposition in the body. [2]
Oral drugs are normally taken as tablets or capsules. The drug (active substance) itself needs to be soluble in aqueous solution at a controlled rate.Such factors as particle size and crystal form can significantly affect dissolution.
The average independent pharmacy had total sales of approximately $4 million and average prescription sales of approximately $3.7 million per location (accounting for 92.5% of all independent pharmacy sales). Over 26% of independent pharmacy owners have ownership in two or more pharmacies. [2]
In pharmacology, clearance is a pharmacokinetic parameter representing the efficiency of drug elimination. This is the rate of elimination of a substance divided by its concentration. [1]