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A phosphodiesterase type 5 inhibitor ... and are used in the treatment of erectile dysfunction (ED). Sildenafil was the first effective oral treatment available for ED.
These phosphodiesterase inhibitors are used primarily as remedies for erectile dysfunction, as well as having some other medical applications such as treatment of pulmonary hypertension. Dipyridamole also inhibits PDE5. This results in added benefit when given together with nitric oxide or statins.
Avanafil is a PDE5 inhibitor approved for erectile dysfunction by the FDA on April 27, 2012 [2] and by EMA on June 21, 2013. [3] Avanafil is sold under the brand names Stendra and Spedra.
Often, erectile dysfunction can instead be treated non-pharmacologically, by identifying and addressing a psychogenic cause of the disease. [18] Particular caution should be used when prescribing PDE5 inhibitors for erectile dysfunction for patients receiving protease inhibitors, like Atazanavir, which are used to treat HIV.
Inhibitors of PDE can prolong or enhance the effects of physiological processes mediated by cAMP or cGMP by inhibition of their degradation by PDE. [13] Sildenafil (Viagra) is an inhibitor of cGMP-specific phosphodiesterase type 5, which enhances the vasodilatory effects of cGMP in the corpus cavernosum and is used to treat erectile dysfunction.
It belongs to a class of medications called phosphodiesterase type 5 inhibitors, or PDE5 inhibitors. You might have heard of other PDE5 inhibitors like: Levitra (vardenafil)
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