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A skin biopsy for the measurement of epidermal nerve fiber density is an increasingly common technique for the diagnosis of small fiber peripheral neuropathy. [13] Physicians can biopsy the skin with a 3-mm circular punch tool and immediately fix the specimen in 2% paraformaldehyde lysine-periodate or Zamboni's fixative. [20]
Nerve compression syndrome, or compression neuropathy, or nerve entrapment syndrome, is a medical condition caused by chronic, direct pressure on a peripheral nerve. [1] It is known colloquially as a trapped nerve, though this may also refer to nerve root compression (by a herniated disc, for example).
Nerve decompressions are associated with a significant reduction in pain, in some cases the complete elimination of pain. [ 64 ] [ 58 ] [ 59 ] For patients with diabetic peripehral neuropathy (which affects 30% of diabetes patients [ 65 ] ) and superimposed nerve compression, this may be treatable with multiple nerve decompressions.
Electroanalgesia is a form of analgesia, or pain relief, that uses electricity to ease pain and belongs to a type of neurotherapy.Electrical devices can be internal or external, at the site of pain (local) or delocalized throughout the whole body.
Laser evoked potentials (LEPs) are measurements of cortical responses using lasers to selectively stimulate thermonociceptors in the skin. Lasers can emit a radiant-heat pulse stimulus to selectively activate A-delta and C free nerve endings. LEP abnormalities may be indicative of neuropathic pain, while a normal LEP is often more ambiguous.