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Amide reduction is a reaction in organic synthesis where an amide is reduced to either an amine or an aldehyde functional group. [ 1 ] [ 2 ] Catalytic hydrogenation
SMEAH is a versatile hydride reducing agent. It readily converts epoxides, aldehydes, ketones, carboxylic acids, esters, acyl halides, and anhydrides to the corresponding alcohols. Nitrogen derivates such as amides, nitriles, imines, and most other organonitrogen compounds are reduced to the corresponding amines. Nitroarenes can be converted to ...
Lithium aluminium hydride, commonly abbreviated to LAH, is an inorganic compound with the chemical formula Li[Al H 4] or LiAlH 4. It is a white solid, discovered by Finholt, Bond and Schlesinger in 1947. [4] This compound is used as a reducing agent in organic synthesis, especially for the reduction of esters, carboxylic acids, and amides.
Amide reduction: Amines, aldehydes Reagent: lithium aluminium hydride followed by hydrolysis Vilsmeier–Haack reaction: Aldehyde (via imine) POCl 3, aromatic substrate, formamide Bischler–Napieralski reaction: Cyclic aryl imine: POCl 3, SOCl 2, etc. Tautomeric chlorination: Imidoyl chloride: Oxophilic halogenating agents, e.g. COCl 2 or SOCl 2
Sodium triacetoxyborohydride (STAB, NaBH(OAc) 3) is a common reducing agent for reductive aminations. STAB selectively reduces the imine intermediate formed through dehydration of the molecule. [8] STAB is a weaker reductant than NaBH 4, and can preferentially reduce the imine group in the presence of other reduction-sensitive functional groups ...
The Leuckart reaction is the chemical reaction that converts aldehydes or ketones to amines. The reaction is an example of reductive amination. [1] The reaction, named after Rudolf Leuckart, uses either ammonium formate or formamide as the nitrogen donor and reducing agent. It requires high temperatures, usually between 120 and 130 °C; for the ...
DIBAL reacts slowly with electron-poor compounds and more quickly with electron-rich compounds. Thus, it is an electrophilic reducing agent whereas LiAlH 4 can be thought of as a nucleophilic reducing agent. DIBAL is useful in organic synthesis for a variety of reductions, including converting carboxylic acids, their derivatives, and nitriles ...
Iodoacetamide (IAA) is an organic compound with the chemical formula I C H 2 CO NH 2. It is an alkylating agent used for peptide mapping purposes. Its actions are similar to those of iodoacetate. It is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.