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The puzzle is known to have appeared as early as 1981, in the book Super Strategies For Puzzles and Games. In this version of the puzzle, A, B, C and D take 5, 10, 20, and 25 minutes, respectively, to cross, and the time limit is 60 minutes. [6] [7] In all these variations, the structure and solution of the puzzle remain the same.
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into the ...
"Take" for R, abbreviation of the Latin word recipe, meaning "take". Most abbreviations can be found in the Chambers Dictionary as this is the dictionary primarily used by crossword setters. However, some abbreviations may be found in other dictionaries, such as the Collins English Dictionary and Oxford English Dictionary .
Two or more antidepressants taken together, from either the same or different classes (affecting the same area of the brain, often at a much higher level). An antipsychotic combined with an antidepressant, particularly atypical antipsychotics such as aripiprazole (Abilify), quetiapine (Seroquel), olanzapine (Zyprexa), and risperidone (Risperdal).
Full Antidepressants List: SSRIs, SNRIs, TCAs & Others. Antidepressants: the most common prescription medication among cool people like artists, fictional type As, film protagonists and yourself.
The major limitation of SSRIs concerns their delay of action. It appears that the clinical efficacy of SSRIs becomes evident only after a few weeks. [223] SSRIs can be combined with a host of other drugs including bupropion, α 2 adrenergic antagonists (e.g., yohimbine) as well as some of the atypical antipsychotics. The augmentation agents are ...
An acrostic puzzle published in State Magazine in 1986. An acrostic is a type of word puzzle, related somewhat to crossword puzzles, that uses an acrostic form. It typically consists of two parts. The first part is a set of lettered clues, each of which has numbered blanks representing the letters of the answer.
For example, cocaine, which non-selectively inhibits the reuptake of serotonin, norepinephrine, and dopamine, is an SRI but not an SSRI. SRIs are used predominantly as antidepressants (e.g., SSRIs, SNRIs, and TCAs), though they are also commonly used in the treatment of other psychological conditions such as anxiety disorders and eating disorders.