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Ciclopirox is a medication used for the treatment of moderate onychomycosis of fingernails and toenails, [3] and for the treatment of seborrheic dermatitis. [ 4 ] In 2022, it was the 247th most commonly prescribed medication in the United States, with more than 1 million prescriptions.
Since hair naturally grows in follicles in groups of 1 to 4 hairs, transplantation takes advantage of these naturally occurring follicular units. This achieves a more natural appearance by matching hair for hair through Follicular unit transplantation (FUT).
Specifically, ketoconazole or ciclopirox are effective. [10] Seborrhoeic dermatitis of the scalp is often treated with shampoo preparations of ketoconazole zinc pyrithione, and selenium, although the latter has been partly discontinued due to concerns of selenium in higher concentrations being carcinogenic. [11]
The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer (see figure), where each zinc is bonded to two sulfur and three oxygen centers. [3]
Piroctone olamine (INN; also known as piroctone ethanolamine) is a compound sometimes used in the treatment of fungal infections. [1] Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone was first synthesized in 1979 by Schwarzkopf-Henkel (Germany).
Selenium disulfide is available in the form of a prescription drug as a 2.25% medical shampoo. [18] [19] In the United States, a 1% strength is available over-the-counter, and a 2.5% strength is also available with a prescription. [19]
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