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Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections. [1] AP-1 controls a number of cellular processes including differentiation, proliferation, and apoptosis. [2]
The AP-1 binding site, also known as the AP-1 promoter site, is a DNA sequence to which AP-1 transcription factors are able to bind. [1] The AP-1 binding site, in humans, has a nucleotide sequence of ATGAGTCAT, where A corresponds to adenine , T corresponds to thymine , G corresponds to guanine , and C corresponds to cytosine .
Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor ...
The experiment identifies 200 regulated genes. Of those, 40 (20%) turn out to be on a list of cholesterol genes as well. Based on the overall prevalence of the cholesterol genes (0.5%) one expects an average of 1 cholesterol gene for every 200 regulated genes, that is, 0.005 times 200.
AP-1 complex subunit sigma-2 is a protein that in humans is encoded by the AP1S2 gene. [5] [6] [7] ... Mutations of the AP1S2 gene cause the Pettigrew syndrome, [8] ...
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene. [5] [6] [7]Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors.
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8907 11767 Ensembl ENSG00000072958 ENSMUSG00000003033 UniProt Q9BXS5 P35585 RefSeq (mRNA) NM_001130524 NM_032493 NM_007456 RefSeq (protein) NP_001123996 NP_115882 NP_031482 Location (UCSC) Chr 19: 16.2 – 16.25 Mb Chr 8: 72.99 – 73.01 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene. Function The ...