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In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.
Furthermore, PKC-θ plays a role in the activation of transcription factor NF-AT (nuclear factor of activated T cells). [10] Thus, PKC-θ promotes inflammation in effector T cells. [6] PKC-θ plays a role in the activation of ILC2 and contribute to the proliferation of Th2 cells. [11] The kinase PKC-θ is crucial for function of Th2 and Th17. [6]
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol.PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.
18759 Ensembl ENSG00000163558 ENSMUSG00000037643 UniProt P41743 Q62074 RefSeq (mRNA) NM_002740 NM_008857 RefSeq (protein) NP_002731 NP_032883 Location (UCSC) Chr 3: 170.22 – 170.31 Mb Chr 3: 31.05 – 31.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene. Function This gene encodes a member of the ...
[4] [44] [45] [46] One example of a protein that binds to adaptor proteins and become activated is PLC that is very important in the lymphocyte signal pathways. PLC is responsible for PKC activation, via DAG and Ca 2+, which leads to phosphorylation of CARMA1 molecule, and formation of CBM complex.
Protein kinase C eta type is an enzyme that in humans is encoded by the PRKCH gene. [5] [6] [7] Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be ...