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Truvada was previously only approved by the U.S. Food and Drug Administration (FDA) to treat HIV in those already infected. In 2012, the FDA approved the drug for use as pre-exposure prophylaxis (PrEP), based on growing evidence that the drug was safe and effective at preventing HIV in populations at increased risk of infection. [41]
Pre-exposure prophylaxis (PrEP) provides HIV-negative individuals with medication—in conjunction with safer-sex education and regular HIV/STI screenings—in order to reduce the risk of acquiring HIV. [40] In 2011, the journal Science gave the Breakthrough of the Year award to treatment as prevention. [41]
Pre-exposure prophylaxis (PrEP), is the use of medications to prevent the spread of disease in people who have not yet been exposed to a disease-causing agent. Vaccination is the most commonly used form of pre-exposure prophylaxis ; other forms of pre-exposure prophylaxis generally involve drug treatment, known as chemoprophylaxis .
Using male or female condom during sex, [5] being tested for HIV and sexually transmitted infections, [5] having a voluntary medical male circumcision, [5] using harm reduction services for people who inject and use drugs, [5] antiretroviral drugs (ARVs) (including oral Pre-exposure prophylaxis (PrEP) and long acting products, [5] dapivirine ...
Patients are advised to discuss any history of bone issues, kidney issues, or hepatitis B infection with their healthcare provider. [19] Effectiveness of PrEP for prevention of infection is reliant on an individual's ability to take the medication consistently. [20] Emtricitabine/tenofovir is also used for HIV post-exposure prophylaxis. People ...
Efavirenz is not effective against HIV-2, as the pocket of the HIV-2 reverse transcriptase has a different structure, which confers intrinsic resistance to the NNRTI class. [ 20 ] As most NNRTIs bind within the same pocket, viral strains which are resistant to efavirenz are usually also resistant to the other NNRTIs, nevirapine and delavirdine .
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