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Leukocyte esterase (LE) is an esterase (a type of enzyme) produced by leukocytes (white blood cells). A leukocyte esterase test (LE test) is a urine test for the presence of white blood cells and other abnormalities associated with infection. White blood cells in the urine can indicate a urinary tract infection (UTI). Positive test results may ...
The test for leukocyte esterase is indicative and does not replace microscopic examination of urine. [19] It is normal to find up to 3 (occasionally 5) leukocytes per high power field (40X) in a urine sample, with women having slightly higher results owing to vaginal contamination. [citation needed] Higher numbers indicate urinary infection.
In the elderly, the leukocyte esterase test is often positive even in the absence of an infection. [citation needed] The urine dipstick test is readily available and provides fast, but often unreliable results. Some organisms such as chlamydia and Ureaplasma urealyticum will produce a negative leukocyte esterase reaction.
[65] [66] During urinary tract infections, waste products of bacterial metabolism can cause the urine to become alkaline. [67] Urine pH may be monitored to help prevent the formation of kidney stones or to avoid side effects of some drugs, [ 68 ] such as high-dose methotrexate therapy, in which crystals that cause kidney damage can form if the ...
They are more common in women than men, but similar between anatomies while carrying indwelling catheters. [7] [18] In women, they are the most common form of bacterial infection. [19] Up to 10% of women have a urinary tract infection in a given year, and half of women have at least one infection at some point in their lifetime.
The standard definition of a reference range for a particular measurement is defined as the interval between which 95% of values of a reference population fall into, in such a way that 2.5% of the time a value will be less than the lower limit of this interval, and 2.5% of the time it will be larger than the upper limit of this interval, whatever the distribution of these values.
The most common type of cast, hyaline casts are solidified Tamm–Horsfall mucoprotein secreted from the tubular epithelial cells of individual nephrons. Low urine flow, concentrated urine, or an acidic environment can contribute to the formation of hyaline casts, and as such, they may be seen in normal individuals in dehydration or vigorous exercise.
In biochemistry, an esterase is a class of enzyme that splits esters into an acid and an alcohol in a chemical reaction with water called hydrolysis (and as such, it is a type of hydrolase). A wide range of different esterases exist that differ in their substrate specificity, their protein structure , and their biological function.