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Methocarbamol, sold under the brand name Robaxin among others, is a medication used for short-term musculoskeletal pain. [3] [4] It may be used together with rest, physical therapy, and pain medication. [3] [5] [6] It is less preferred in low back pain. [3] It has limited use for rheumatoid arthritis and cerebral palsy.
Comparison to oral morphine [a] Analgesic Strength (relative) Equivalent dose (10 mg oral morphine) [b] Bioavailability Half-life of active metabolites (hours) Oral-to-parenteral ratio Speed of onset Duration Paracetamol (non-opioid) 1 ⁄ 360: 3600 mg 63–89% 1–4 37 min ; 8 min 5–6 hours Aspirin (NSAID, non-opioid) 1 ⁄ 360: 3600 mg 80 ...
There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity. Nephrotoxicity should not be confused with some medications predominantly excreted by the kidneys needing their dose adjusted for the decreased kidney function (e.g., heparin , lithium).
The therapeutic window (or pharmaceutical window) of a drug is the range of drug dosages which can treat disease effectively without having toxic effects. [25] Medication with a small therapeutic window must be administered with care and control, frequently measuring blood concentration of the drug, to avoid harm.
Acute kidney injury (AKI), previously called acute renal failure (ARF), [1] [2] is a sudden decrease in kidney function that develops within seven days, [3] as shown by an increase in serum creatinine or a decrease in urine output, or both. [4]
Atracurium, the resulting molecule, breaks down spontaneously in the body to inactive compounds and being especially useful in patients with kidney or liver failure. Cis -atracurium is very similar to atracurium except it is more potent and has a weaker tendency to cause histamine release.
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