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Other serious side effects include an increased risk of future cancer and pancreatitis. [2] Those with a genetic deficiency in thiopurine S-methyltransferase are at higher risk of side effects. [2] Use in pregnancy may harm the baby. [2] Mercaptopurine is in the thiopurine and antimetabolite family of medications. [4] [3]
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [8] [9] It may also be used for hiccups and muscle spasms near the end of life, [9] and off-label to treat alcohol use disorder [10] [11] or opioid withdrawal symptoms. [12]
Other severe side effects include unusual or severe tiredness or weakness, as well as yellowing of the skin or the eyes. [41] When baclofen is administered intrathecally, it may cause CNS depression accompanied with cardiovascular collapse and respiratory failure. Tizanidine may lower blood pressure. This effect can be controlled by ...
[81] [82] Concerns regarding the long-term effects of benzodiazepines have been raised since 1980. [83] These concerns are still not fully answered. A review in 2006 of the literature on use of benzodiazepine and nonbenzodiazepine hypnotics concluded that more research is needed to evaluate the long-term effects of hypnotic drugs. [84]
Two generic azathioprine oral tablets, 50 mg each. Nausea and vomiting are common adverse effects, especially at the beginning of treatment. Such cases are met with taking azathioprine after meals or transient intravenous administration. Side effects that are probably hypersensitivity reactions include dizziness, diarrhea, fatigue, and rashes ...
But some research has noted rare but serious side effects of once-weekly, 2.4-milligram (mg) ... In a two-year clinical trial cited in the drug’s prescribing label, acute pancreatitis — sudden ...
Side effects may include constipation, low blood potassium, and stools that are dark. [ 1 ] [ 3 ] With long-term use, sweat may turn blue. [ 3 ] It mainly works by trapping the toxic monovalent cations in its crystal lattice after ion-exchange with potassium or ammonium cations and thus preventing the absorption of thallium and radio-caesium ...