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Human iron metabolism is the set of chemical reactions that maintain human homeostasis of iron at the systemic and cellular level. Iron is both necessary to the body and potentially toxic. Controlling iron levels in the body is a critically important part of many aspects of human health and disease.
Parts-per-million cube of relative abundance by mass of elements in an average adult human body down to 1 ppm. About 99% of the mass of the human body is made up of six elements: oxygen, carbon, hydrogen, nitrogen, calcium, and phosphorus. Only about 0.85% is composed of another five elements: potassium, sulfur, sodium, chlorine, and magnesium ...
The body of an adult human contains about 4 grams (0.005% body weight) of iron, mostly in hemoglobin and myoglobin. These two proteins play essential roles in oxygen transport by blood and oxygen storage in muscles. To maintain the necessary levels, human iron metabolism requires a minimum of iron in the diet.
Human nutrition deals with the provision of essential nutrients in food that are necessary to support human life and good health. [1] Poor nutrition is a chronic problem often linked to poverty, food security , or a poor understanding of nutritional requirements. [ 2 ]
Hephaestin, a ferroxidase that can oxidize Fe 2+ to Fe 3+ and is found mainly in the small intestine, helps ferroportin transfer iron across the basolateral end of the intestine cells. In contrast, ferroportin is post-translationally repressed by hepcidin, a 25-amino acid peptide hormone. The body regulates iron levels by regulating each of ...
Trace metals within the human body include iron, lithium, zinc, copper, chromium, nickel, cobalt, vanadium, molybdenum, manganese and others. [ 1 ] [ 2 ] [ 3 ] Some of the trace metals are needed by living organisms to function properly and are depleted through the expenditure of energy by various metabolic processes of living organisms.
The four organogenic elements, namely carbon, hydrogen, oxygen, and nitrogen , that comprise roughly 96% of the human body by weight, [7] are usually not considered as minerals (nutrient). In fact, in nutrition, the term "mineral" refers more generally to all the other functional and structural elements found in living organisms.
Four to three Ga, anaerobic prokaryotes arose, and the atmosphere was full of H 2 S and highly reductive. Thus most zinc was in the form of insoluble ZnS . However, because seawater at the time was slightly acidic, some Zn(II) was available in its ionic form and became part of early anaerobic prokaryotes' external proteases , external nucleases ...