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Bafilomycin A1, B1 and C1 were first isolated from Streptomyces griseus in 1983. [11] During a screen seeking to identify microbial secondary metabolites whose activity mimicked that of two cardiac glycosides, bafilomycin C1 was identified as an inhibitor of P-ATPase with a k i of 11 μM.
Streptomyces halstedii is a bacterium species from the genus of Streptomyces which has been isolated from deeper soil layers. [1] [2] Streptomyces halstedii produces magnamycin B, vicenistatin deltamycin A2, deltamycin A3, bafilomycin B1 and bafilomycin C1.
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GABA transporter 2 (GAT2; SLC6A13) also known as sodium- and chloride-dependent GABA transporter 2 is one of four GABA transporters, GAT1 (), GAT2 (SLC6A13), GAT3 and BGT1 (). [1]
Valinomycin is a dodecadepsipeptide, that is, it is made of twelve alternating amino acids and esters to form a macrocyclic molecule. The twelve carbonyl groups are essential for the binding of metal ions, and also for solvation in polar solvents.
There are several families that function in amino acid transport, some of these include: TC# 2.A.3 - Amino Acid-Polyamine-Organocation (APC) Superfamily; TC# 2.A.18 - Amino Acid/Auxin Permease (AAAP) Family