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Trichuris trichiura, Trichocephalus trichiuris or whipworm, is a parasitic roundworm (a type of helminth) that causes trichuriasis (a type of helminthiasis which is one of the neglected tropical diseases) when it infects a human large intestine.
A number of such organisms are currently being investigated for their use as treatment, including: Trichuris suis ova, [6] [7] commonly known as pig whipworm eggs; Necator americanus, [8] commonly known as hookworms; Trichuris trichiura ova, [9] commonly referred to as human whipworm eggs; and Hymenolepis diminuta, commonly known as rat tapeworm.
Trichuriasis, also known as whipworm infection, is an infection by the parasitic worm Trichuris trichiura (whipworm). [2] If the infection is only with a few worms, there are often no symptoms. [ 1 ] In those who are infected with many worms, there may be abdominal pain , fatigue and diarrhea . [ 1 ]
Trichuris suis is a whipworm; the variations in thickness of the anterior and posterior segments give the parasite the characteristic "whip-like" appearance. Adult females measure 6 to 8 cm and adult males 3 to 4 cm. T. suis eggs are oval (60 × 25 μm) and yellow-brown with bipolar plugs. [1] T. suis is also used in helminthic therapy studies. [2]
Mebendazole is given twice a day for three consecutive days, while albendazole is given as a single dose. WHO recommends annual treatment in areas where between 20 and 50% of people are infected, and a twice-a-year treatment if it is over 50%; and in low-risk situations (i.e. less than 20% prevalence) case-by-case treatment.
Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations, including roundworm, hookworm, whipworm, threadworm (pinworm), and the intestinal form of trichinosis prior to its spread into the tissues beyond the digestive tract.
The optimal duration of treatment for patients with disseminated infections is not clear. [10] Treatment of strongyloidiasis can be difficult and if ceasing treatment before being entirely cleared Strongyloides via the autoinfective cycle has been known to live in individuals for decades; [22] even after initial or inadequate sustained ...
It was in the 1950s that it was established that whipworms have direct life cycle, required no other animals (vectors or intermediate hosts for their transmission) and rather fragile eggs unlike most other helminths. [15] It is now known that all whipworm species have a similar general life cycle. [2] [24] Whipworm eggs are first ingested by ...