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[6] [3] A 2014 Cochrane review concluded that "There is no good evidence for or against the effectiveness of OTC [over the counter] medicines in acute cough". [1] Some cough medicines may be no more effective than placebos for acute coughs in adults, including coughs related to upper respiratory tract infections. [ 7 ]
Guaifenesin might act as an expectorant by increasing the volume and reducing the viscosity of secretions in the trachea and bronchi via stimulation of the gastric mucosa. . This stimulation leads to an increased parasympathetic activity in the respiratory tract via the so-called gastro-pulmonary reflex, although some in vitro studies suggested that it might also act directly on the ...
Dextromethorphan, sold under the brand name Robitussin among others, is a cough suppressant used in many cough and cold medicines. [6] In 2022, the US Food and Drug Administration (FDA) approved the combination dextromethorphan/bupropion to serve as a rapid-acting antidepressant in people with major depressive disorder.
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The third and fourth plateaus (7.5 mg/kg and over) cause profound alterations in consciousness, and users often report out-of-body experiences or temporary psychosis. [15] [16] This results in a sort of flanging (speeding up and/or slowing down) of sensory input, which is another characteristic effect of recreational use.
Pseudoephedrine is widely available over-the-counter (OTC) in both single-drug and combination preparations. [30] [22] [13] [2] Availability of pseudoephedrine has been restricted starting in 2005 as it can be used to synthesize methamphetamine. [13] [2] Phenylephrine has replaced pseudoephedrine in many over-the-counter oral decongestant ...