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Early antiparasitics were ineffective, frequently toxic to patients, and difficult to administer due to the difficulty in distinguishing between the host and the parasite. [ 4 ] Between 1975 and 1999 only 13 of 1,300 new drugs were antiparasitics, which raised concerns that insufficient incentives existed to drive development of new treatments ...
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A schistosomicide is a drug used to combat schistosomiasis. [1] ... Examples listed in MeSH include: [2] amoscanate; arteether; artemether; chloroxylenol; hycanthone ...
Anthelmintic resistance in parasites is widespread; drug resistance exists in all livestock hosts and to all anthelmintic drug classes. [13] This is a major threat to the sustainability of modern ruminant livestock production, resulting in reduced productivity, compromised animal health and welfare, [ 12 ] and increased greenhouse gas emissions ...
An ectoparasiticide is an antiparasitic drug used in the treatment of ectoparasitic infestations. [1] These drugs are used to kill the parasites that live on the body surface. Permethrin , sulfur , lindane , dicophane , benzyl benzoate , ivermectin and crotamiton are well known ectoparasiticides. [ 2 ]
Chemically, nitazoxanide is the prototype member of the thiazolides, a class of drugs which are synthetic nitrothiazolyl-salicylamide derivatives with antiparasitic and antiviral activity. [4] [6] [8] Tizoxanide, an active metabolite of nitazoxanide in humans, is also an antiparasitic drug of the thiazolide class. [4] [9]
Mismatched drug combinations, for example having an 'unprotected' period where one drug dominates can seriously increase the likelihood of selection for resistant parasites. Ecologically there is a linkage between the level of transmission and the development of resistance, however at present this still remains unclear.
Several drugs are available for treating intestinal infections, the most effective of which has been shown to be paromomycin (also known as Humatin); iodoquinol (also known as Yodoxin) is used in the US; and diloxanide furoate (also known as Furamide) is used in certain other countries.