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Mycophenolate mofetil, a prodrug form of mycophenolic acid used in medicine. Mycophenolate mofetil is the morpholino ethyl ester of mycophenolic acid; the ester masks the carboxyl group. [42] Mycophenolate mofetil is reported to have a pKa values of 5.6 for the morpholino moiety and 8.5 for the phenolic group.
Mycophenolate mofetil is the prodrug of mycophenolic acid (MPA) and widely used for the prevention of acute rejection after solid organ transplantation. MPA could be metabolized to AcMPAG, which is responsible for adverse effects of MMF therapy such as leucopenia or gastrointestinal toxicity .
This was the first antibiotic compound isolated in pure and crystallised form. Though the original compound was abandoned in clinical practice due to its adverse effects, its chemical derivative mycophenolate mofetil became the drug of choice as an immunosuppressant in kidney, heart, and liver transplantations. [3]
"Mycophenolic acid" is the acid you linked to; this is the active substance. "Mycophenolate mofetil" is a different molecule (no idea why the WHO lists it as a synonym) – it is the ester of mycophenolic acid and the structure referred to as "mofetil" in your other link. Again, I've no idea why "mycophenolate mofetil hydrochloride" is given as ...
As inhalers they are used to treat asthma, as nasal sprays to treat hay fever (allergic rhinitis) and as eye drops for allergic conjunctivitis. [2] Finally, in oral form, they are used to treat the rare condition of mastocytosis .
Diquafosol (tradename Diquas) is a pharmaceutical drug for the treatment of dry eye disease. It was approved for use in Japan in 2010. [1] It is formulated as a 3% ophthalmic solution of the tetrasodium salt. Its mechanism of action involves agonism of the P2Y2 purinogenic receptor. [2]