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Sodium channel blockers are also used as local anesthetics and anticonvulsants. [5] Sodium channel blockers have been proposed for use in the treatment of cystic fibrosis, [6] but current evidence is mixed. [7] It has been suggested that the analgesic effects of some antidepressants may be mediated in part via sodium channel blockade. [8]
Pages in category "Sodium channel blockers" The following 77 pages are in this category, out of 77 total. This list may not reflect recent changes. A. Ajmaline;
An epithelial sodium channel blocker is a sodium channel blocker that is selective for the epithelial sodium channel. An example is amiloride , which is used in the treatment of hypertension . [ 1 ]
Conventional antiepileptic drugs may block sodium channels or enhance γ-aminobutyric acid function. Several antiepileptic drugs have multiple or uncertain mechanisms of action. [ 8 ] Next to the voltage-gated sodium channels and components of the GABA system, their targets include GABA A receptors , the GABA transporter type 1 , and GABA ...
Common anticonvulsants used to treat neuropathy are gabapentinoids (calcium channel blockers) and carbamazapine (sodium channel blocker). [8] There is some evidence that anticonvulsants may also help with inflammatory pain through reduction of nociceptor hyper-excitability originally due to damage to surrounding tissue. [9] Examples: Gabapentin ...
Examples of targets for modulators include: Voltage-gated ion channels. Calcium channel: see also Calcium channel blocker, Calcium channel opener; Potassium channel: see also Potassium channel blocker, Potassium channel opener; Sodium channel: see also Sodium channel blocker, Sodium channel opener
For example, TTX can bind and inactivate voltage-gated sodium channels, despite the fact that TTX is much larger and chemically different than sodium ions. Given the disparities in size and chemical properties between TTX and a sodium ion, this is an example of structure being used to block usually specific channels.
It is a sodium channel blocker and is classified as a Class 1a anti-arrhythmic agent. [3] [4] Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility. [5] [6] Disopyramide also has general anticholinergic effects which contribute to unwanted adverse effects. Disopyramide is ...