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itch.io (stylized in all lowercase) is a website for users to host, sell and download indie video games, indie role-playing games, game assets, comics, zines and music. Launched in March 2013 by Leaf Corcoran, the service hosts over 1,000,000 products as of November 2024 [update] .
Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. [ 2 ] [ 3 ] The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. [ 4 ]
PP2 is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck ( IC 50 =4 nM ), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100 μM) and JAK2 (50 μM).
GOG.com offers DRM-free downloading in mp4 format and streaming of video in standard and DRM-free HTML fashion which doesn't bind users to any specific platforms or devices. Movies are made available in Full HD 1080p, 720p and 576p for limited bandwidth or download quotas; however, a few titles do not have the Full HD 1080p format available.
The Impulse Client was replaced by the GameStop PC Downloads App, which allows users to download content purchased prior to the discontinuation of Impulse. New digital PC game purchases are made through the GameStop.com store. Support for legacy Impulse/GameStop App game downloads was handled for some time through Game Stop Guest Care. [9]
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Schamberg's disease is caused by leaky blood vessels near the surface of the skin, capillaries, which allow red blood cells to slip through into the skin. [3] The red blood cells in the skin then fall apart and release their iron, which is released from hemoglobin. [3] The iron causes a rust color and this accounts for the orange tint of the ...
Two game bundles offered by itch.io and Humble Bundle raised over $6 million and $20 million for Ukraine aid support, respectively. [86] [87] Epic Games made all proceeds from Fortnite during the last two weeks of March 2022 go to charitable aid for Ukraine, and raised over $144 million. [88] [89]