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Vitamin B 12 deficiency can be determined, but not always. [14] This means it measures forms of vitamin B 12 that are "active" and can be used by the body, as well as the "inactive" forms, which cannot. [150] Vitamin B 12 deficiency can be found within normal levels, so clinical symptoms should be taken into account when a diagnosis is made. [2]
Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide. [14] Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition. [8] It more commonly affects people of northern European descent. [2]
Lack of vitamin B12 can cause megaloblastic anemia—a condition characterized by larger than normal red blood cells in a smaller than normal amount. This causes fatigue, paleness in the skin ...
Megaloblastic anemia, the most common cause of macrocytic anemia, is due to a deficiency of either vitamin B 12, folic acid, or both. [81] Deficiency in folate or vitamin B 12 can be due either to inadequate intake or insufficient absorption. Folate deficiency normally does not produce neurological symptoms, while B 12 deficiency does.
Symptoms “A B12 deficiency can cause physical and neurological symptoms, and research is also growing to support that it can also cause psychological issues as well,” says Shapiro.
Causes of vitamin B12 deficiency. There are a few reasons why someone might develop a vitamin B12 deficiency. ... People who have had stomach surgery for weight loss, older adults, and people with ...
Nutritional causes are vitamin and mineral deficiencies and non-nutritional causes include infections. The number one cause of this type of anemia, however, is iron deficiency. [12] An insufficient intake of iron, Vitamin B12, and folic acid impairs the bone marrow function. The lack of iron within a person's body can also stem from ulcer bacteria.
Older adults. Older adults’ ability to absorb B12 becomes compromised and a deficiency is more likely, says Gans. ... Over time, a deficiency of B12 can cause problems with balance, confusion ...