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Oral rabies vaccination (ORV) programs have been used in many countries in an effort to control the spread of rabies and limit the risk of human contact with the rabies virus. [42] ORV programs were initiated in Europe in the 1980s, Canada in 1985, and in the United States in 1990. [54]
The human diploid cell rabies vaccine was started in 1967. Less expensive purified chicken embryo cell vaccine and purified vero cell rabies vaccine are now available. [69] A recombinant vaccine called V-RG has been used in Belgium, France, Germany, and the United States to prevent outbreaks of rabies in undomesticated animals. [77]
2003 – First vaccine for Argentine hemorrhagic fever. [16] 2006 – First vaccine for human papillomavirus (which is a cause of cervical cancer) 2006 – First herpes zoster vaccine for shingles; 2011 – First vaccine for non-small-cell lung carcinoma (comprises 85% of lung cancer cases) 2012 – First vaccine for hepatitis E [17]
The US Centers for Disease Control and Prevention (CDC) recommends vaccination with two doses of the Jynneos mpox vaccine for people in the US at high risk of catching the virus.
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Canine mediated human rabies has been eliminated since 1980, and lyssaviruses have not been found in bat populations since 1954. [98] The last human death due to rabies occurred in 1980 (following a dog bite), [99] while the last case of rabies detected in a dog was in 2011. [100] Rabies was detected in a fox in 2018. [101]
The Advisory Committee on Immunization Practices (ACIP) recommends the rabies PrEP vaccine to people who have an increased risk of rabies exposure due to their job or location.
Interestingly, the rabies virus vaccine that was created using the SAD-B19 complex, which includes the L-P protein, was utilized in the creation of a vaccine for SARS-CoV-2. The S1 protein from SARS-CoV-2 was inserted into the rabies virus vaccine vector to create a new vaccine that was shown to be effective in protecting against COVID-19.