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If a person is known to usually stop convulsing after only one or two diazepam doses, it may be preferable because sedative after effects will be less than if a single dose of lorazepam is given (diazepam anticonvulsant/sedative effects wear off after 15–30 minutes, but lorazepam effects last 12–24 hours). [100]
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
[citation needed] For example, the equivalent dose of diazepam in an elderly individual on lorazepam may be half of what would be expected in a younger individual. [7] [8] Equivalent doses of benzodiazepines differ as much as 20 fold. [9] [10] [11]
The consensus is to reduce dosage gradually over several weeks, e.g. 4 or more weeks for diazepam doses over 30 mg/day, [1] with the rate determined by the person's ability to tolerate symptoms. [120] The recommended reduction rates range from 50% of the initial dose every week or so, [121] to 10–25% of the daily dose every 2 weeks. [120]
Commonly prescribed benzodiazepines in the U.S. are Valium (diazepam) and Ativan (lorazepam), which are used for muscle relaxation and to control anxiety and seizures.
Benzodiazepine dependence develops with long-term use, even at low therapeutic doses, [2] often without the described drug seeking behavior and tolerance. [ 3 ] [ 4 ] Addiction consists of people misusing or craving the drug, not to relieve withdrawal symptoms, but to experience its euphoric or intoxicating effects.
The end of the holiday weekend added two fresh examples of a historic shift on Wall Street: More CEOs than ever are heading for the exits. Over the past 24 hours, the leaders of chipmaker Intel ...
Nevertheless, as long as the drug is present it will exert subtle effects within the body. These effects may become apparent during continued use or may appear as withdrawal symptoms when dosage is reduced or the drug is stopped. [citation needed] ***Equivalent doses are based on clinical experience but may vary between individuals. [34]
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