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Bag and contents of a well-known early brand of synthetic cannabinoids named Spice that contains herbs covered with synthetic cannabinoids, now illegal throughout much of the world. Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids (THC, CBD and many others) in cannabis plants ...
JWH-073, a synthetic cannabinoid, is an analgesic chemical from the naphthoylindole family that acts as a full agonist [3] at both the CB 1 and CB 2 cannabinoid receptors. It is somewhat selective for the CB 1 subtype, with affinity at this subtype approximately 5× the affinity at CB 2. [4]
JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
Sweden's public health agency classified CUMYL-PEGACLONE as a narcotic substance, on January 18, 2019. [12]In the United States, the DEA has temporarily placed CUMYL-PEGACLONE into Schedule I status starting on December 12th, 2023 for up to 2 years, during which it's possible the DEA could file for permanent scheduling within those 2 years.
Compared with classical cannabinoids, synthetic cannabinoids differ structurally. Some common synthetic cannabinoids are available in the market such as JWH-018, which is the most well-known naphthoylindole and JWH-250, a phenylacetylindole. They are sold under the brand name ”Spice” as a recreational drug over the past decade. [4]
Cannabinoids and their K i values [a] Name Class K i / nM at CB 1 K i / nM at CB 2 Selectivity Structure JWH-004: Naphthoylindole: 48 ± 13: 4 ± 1.5: CB 2 (12x) JWH-007 [5] Naphthoylindole: 9.5 ± 4.5: 2.9 ± 2.6: CB 2 (3.3x) JWH-009: Naphthoylindole >10000: 141 ± 14: CB 2 (>70x) JWH-011: Naphthoylindole: JWH-015 [5] Naphthoylindole: 164 ± ...
Marketed under the names spice, spike, flamingo, or K2 — this underground drug has become one of the most inexpensive and dangerous ways to get high, reports say. Videos surfacing online have ...
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