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  2. Alendronic acid - Wikipedia

    en.wikipedia.org/wiki/Alendronic_acid

    Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget's disease of bone. [4] It is taken by mouth. [ 4 ] Use is often recommended together with vitamin D , calcium supplementation , and lifestyle changes.

  3. Bisphosphonate - Wikipedia

    en.wikipedia.org/wiki/Bisphosphonate

    Long-term treatment with bisphosphonates produces anti-fracture and bone mineral density effects that persist for 3–5 years after an initial 3–5 years of treatment. [2] The bisphosphonate alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%; zoledronate reduces the risk of hip fractures by 38% and of vertebral ...

  4. Discovery and development of bisphosphonates - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    The primary inhibiting action of the first generation of bisphosphonates on osteoclasts is by inducing apoptosis. The mechanism of action is apparently by the formation of an ATP analogue or metabolite of the bisphosphonates like etidronic acid and clodronic acid. The ATP analogue accumulates in the cytosol of the osteoclast with a cytotoxic ...

  5. Alendronic acid/colecalciferol - Wikipedia

    en.wikipedia.org/wiki/Alendronic_acid/colecalciferol

    Alendronic acid/colecalciferol, sold under the brand name Fosamax Plus D among others, is a medication for the treatment of osteoporosis in men or in postmenopausal women. [ 3 ] [ 2 ] [ 4 ] [ 6 ] Alendronic acid/colecalciferol was approved for use in the United States and in the European Union in 2005.

  6. Medication-related osteonecrosis of the jaw - Wikipedia

    en.wikipedia.org/wiki/Medication-related_osteo...

    This type of drug has a high affinity for hydroxyapatite [28] and stays in bone tissue for a long period of time, [29] with alendronate, it has a half-life of approximately ten years. [30] The risk of a patient having MRONJ after discontinuing this medication is unknown. [30]

  7. Onset of action - Wikipedia

    en.wikipedia.org/wiki/Onset_of_action

    A few drugs such as alcohol are absorbed by the lining of the stomach, and therefore tend to take effect much more quickly than the vast majority of oral medications which are absorbed in the small intestine. Gastric emptying time can vary from 0 to 3 hours, [2] and therefore plays a major role in onset of action for orally administered drugs ...

  8. Doctors Say This Is the Best Time to Take Iron Supplements - AOL

    www.aol.com/doctors-best-time-iron-supplements...

    Ideally, you should take your iron supplement first thing in the morning and before foods or other medications to get the best results, says Gregory Castelli, PharmD., director, pharmacy residency ...

  9. Ibandronic acid - Wikipedia

    en.wikipedia.org/wiki/Ibandronic_acid

    Ibandronic acid is a bisphosphonate medication used in the prevention and treatment of osteoporosis and metastasis-associated skeletal fractures in people with cancer. [4] It may also be used to treat hypercalcemia (elevated blood calcium levels).

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