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Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists [2] are a group of medications that disrupt the movement of calcium (Ca 2+) through calcium channels. [3] Calcium channel blockers are used as antihypertensive drugs, i.e., as medications to decrease blood pressure in patients with hypertension.
Calcium channel blocker toxicity is the taking of too much of the medications known as calcium channel blockers (CCBs), either by accident or on purpose. [3] This often causes a slow heart rate and low blood pressure . [ 1 ]
Whether use is safe during pregnancy or breastfeeding is unclear. [2] [10] When used by people with liver problems, and in elderly individuals, doses should be reduced. [10] Amlodipine works partly by vasodilation (relaxing the arteries and increasing their diameter). [10] It is a long-acting calcium channel blocker of the dihydropyridine type ...
Age can affect the choice of medications. Current UK guidelines suggest starting patients over the age of 55 years first on calcium channel blockers or thiazide diuretics. Age and multi-morbidity can affect the choice of medication, the target blood pressure and even whether to treat or not. [61] Anxiety may be improved with the use of beta ...
Chemically, it is based upon a 1,4-thiazepine ring, making it a benzothiazepine-type calcium channel blocker. It is a potent and mild vasodilator of coronary and peripheral vessels, respectively, [29] which reduces peripheral resistance and afterload, though not as potent as the dihydropyridine (DHP) calcium channel blockers
ATC code C08 Calcium channel blockers is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. [1] [2] [3] Subgroup C08 is part of the anatomical group C Cardiovascular system ...
Verapamil is also a Kv voltage gated potassium channel blocker. [37] Calcium channels are also present in the smooth muscle lining blood vessels. By relaxing the tone of this smooth muscle, calcium channel blockers dilate the blood vessels. This has led to their use in treating high blood pressure and angina pectoris. The pain of angina is ...
Isradipine (tradenames DynaCirc, Prescal) is a calcium channel blocker of the dihydropyridine class. It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack. It was patented in 1978 and approved for medical use in 1989. [1]