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Citicoline , also known as cytidine diphosphate-choline (CDP-choline) or cytidine 5'-diphosphocholine is an intermediate in the generation of phosphatidylcholine from choline, a common biochemical process in cell membranes. Citicoline is naturally occurring in the cells of human and animal tissue, in particular the organs.
Structures and localization of the enzymes in the CDP-choline pathway. [1]: 415 The CDP-choline pathway, first identified by Eugene P. Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules.
CDP-choline + 1,2-diacylglycerol CMP + a phosphatidylcholine Thus, the two substrates of this enzyme are CDP-choline and 1,2-diacylglycerol , whereas its two products are CMP and phosphatidylcholine .
Choline-phosphate cytidylyltransferase (EC 2.7.7.15) is an enzyme that catalyzes the chemical reaction CTP + choline phosphate ⇌ {\displaystyle \rightleftharpoons } diphosphate + CDP-choline where the two substrates of this enzyme are CTP and choline phosphate , and the two products are diphosphate and CDP-choline .
Cytidine diphosphate, abbreviated CDP, is a nucleoside diphosphate. It is an ester of pyrophosphoric acid with the nucleoside cytidine. CDP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase cytosine. In Bacillus subtilis and Staphylococcus aureus, CDP-activated glycerol and ribitol are necessary to build wall ...
Choline is a nutrient essential for heart health and brain function and is found in many foods like whole eggs, soybeans, and cruciferous vegetables.