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Citicoline , also known as cytidine diphosphate-choline (CDP-choline) or cytidine 5'-diphosphocholine is an intermediate in the generation of phosphatidylcholine from choline, a common biochemical process in cell membranes. Citicoline is naturally occurring in the cells of human and animal tissue, in particular the organs.
Although multiple pathways exist for the biosynthesis of phosphatidylcholine, the predominant route in eukaryotes involves condensation between diacylglycerol (DAG) and cytidine 5'-diphosphocholine (CDP-choline or citicoline). The conversion is mediated by the enzyme diacylglycerol cholinephosphotransferase.
Choline-phosphate cytidylyltransferase (EC 2.7.7.15) is an enzyme that catalyzes the chemical reaction. CTP + choline phosphate diphosphate + CDP-choline. where the two substrates of this enzyme are CTP and choline phosphate, and the two products are diphosphate and CDP-choline. It is responsible for regulating phosphatidylcholine content in ...
Acetylcholine precursors and prodrugs like choline, phosphatidylcholine , citicoline (CDP-choline), and choline alphoscerate (α-GPC) are known and have been researched. [ 45 ] References
Mn 2+-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.53, Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase, ADPRibase-Mn) is an enzyme with systematic name CDP-choline phosphohydrolase. [ 1 ] [ 2 ] This enzyme catalyses the following chemical reaction
Structures and localization of the enzymes in the CDP-choline pathway. [1]: 415 The CDP-choline pathway, first identified by Eugene P. Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules. [1] [2] The CDP-choline pathway ...