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Mammalian cochlear hair cells are of two anatomically and functionally distinct types, known as outer, and inner hair cells. Damage to these hair cells results in decreased hearing sensitivity, and because the inner ear hair cells cannot regenerate, this damage is permanent. [4] Damage to hair cells can cause damage to the vestibular system and ...
Proliferating supporting cells can acquire hair cell fate in mitotic division. The mouse's neonatal supporting cells proliferate after hair cell death and regenerate hair cells after damage. [26] The neonatal cochlea is resistant to hair cell damage caused by exposure to noise or drugs, which are toxic to the cochlea, or auditory nerve, in vivo ...
The drug is understood to damage multiple regions of the cochlea, causing the death of outer hair cells, as well as damage to the spiral ganglion neurons and cells of the stria vascularis. [27] Long-term retention of cisplatin in the cochlea may contribute to the drug's cochleotoxic potential. [28]
Structural damage to hair cells (primarily the outer hair cells) will result in hearing loss that can be characterized by an attenuation and distortion of incoming auditory stimuli. During hair cell death 'scars' develop, which prevent potassium rich fluid of the endolymph from mixing with the fluid on the basal domain. [ 86 ]
They are thought to damage the hair cells of the cochlea. Long-term exposure to these drugs may cause damage that progresses to the upper turn of the cochlea, impairing hearing or even causing deafness. [6] Glycopeptides, on the other hand, are rarely associated with ototoxicity.
Hearing loss associated with the cochlea is often a result of outer hair cells and inner hair cells damage or death. Outer hair cells are more susceptible to damage, which can result in less sensitivity to weak sounds. Frequency sensitivity is also affected by cochlear damage which can impair the patient's ability to distinguish between ...
Globally, head and neck cancer accounts for 650,000 new cases of cancer and 330,000 deaths annually on average. In 2018, it was the seventh most common cancer worldwide, with 890,000 new cases documented and 450,000 people dying from the disease. [12] The risk of developing head and neck cancer increases with age, especially after 50 years.
Hensen's cells are important in ion metabolism and homeostasis regulation of both endolymph and perilymph, modulation of the hearing sensitivity, regulation and regeneration of the hair cells, and prevention of the cochlea damage. [6] The outer hair cells of the cochlea preprocess the signal by active movements, which can be elevated by ...