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Dobutamine is a direct-acting agent whose primary activity results from stimulation of the β 1-adrenoceptors of the heart, increasing contractility and cardiac output. Since it does not act on dopamine receptors to inhibit the release of norepinephrine (another α 1 agonist), dobutamine is less prone to induce hypertension than is dopamine.
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
Naturally produced hormones norepinephrine and epinephrine or synthetic drugs such as dobutamine can be collectively regarded as beta-agonists. Specifically, dobutamine selectively binds to β1 receptors located on the surface of specialised cardiac muscle cells. [ 16 ]
The first symptoms of kidney failure are silent. Failing kidneys can’t remove extra fluid from the body, nor can they filter molecules like urea, which can be toxic in high dosages, from the blood.
Those included nausea and vomiting, kidney stones, gastroesophageal reflux disease (GERD), sleep issues, stomach cramps, pancreatitis, and gastroparesis (i.e. stomach paralysis).
Dopamine is not proven to have protective properties on the kidneys. [5] Dobutamine can also be used in hypotensive septic shock to increase cardiac output and correct blood flow to the tissues. [76] Dobutamine is not used as often as epinephrine due to its associated side effects, which include reducing blood flow to the gut. [76]
Certain medications, such as dobutamine and milrinone, improve the heart's ability to contract and can also be used. When these measures fail, more advanced options such as mechanical support devices or heart transplantation can be pursued. Cardiogenic shock is a condition that is difficult to fully reverse even with an early diagnosis. [4]
Epinephrine (adrenaline). Activation of β 1 receptors induces positive inotropic, chronotropic output of the cardiac muscle, leading to increased heart rate and blood pressure, secretion of ghrelin from the stomach, and renin release from the kidneys.