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The RALES trial [30] showed that the addition of spironolactone can improve mortality, particularly in severe cardiomyopathy (ejection fraction less than 25%.) The related medication eplerenone was shown in the EPHESUS trial [ 31 ] to have a similar effect, and it is specifically labelled for use in decompensated heart failure complicating ...
An ejection fraction (EF) is the volumetric fraction (or portion of the total) of fluid (usually blood) ejected from a chamber (usually the heart) with each contraction (or heartbeat). It can refer to the cardiac atrium , [ 1 ] ventricle , [ 2 ] gall bladder, [ 3 ] or leg veins, [ 4 ] although if unspecified it usually refers to the left ...
Myocardial infarction or cardiomyopathy causes damage to the myocardium, which impairs the heart's ability to eject blood and, therefore, reduces ejection fraction. This reduction in the ejection fraction can manifest itself as heart failure. Low EF usually indicates systolic dysfunction, and severe heart failure can result in EF lower than 0.2 ...
Heart failure with preserved ejection fraction (HFpEF) is a form of heart failure in which the ejection fraction – the percentage of the volume of blood ejected from the left ventricle with each heartbeat divided by the volume of blood when the left ventricle is maximally filled – is normal, defined as greater than 50%; [1] this may be measured by echocardiography or cardiac catheterization.
Because the Dor procedure restores the left ventricle to its correct, elliptical orientation, it results in a mean ejection fraction increase of 12.5%. This number continues to improve over the patient’s lifetime, and patients can expect to live an extra 4–10 years, which is 3.3% longer than CABG alone with virtually no extra risk. [3]
In clinical cardiology the term "diastolic function" is most commonly referred as how the heart fills. [1] Parallel to "diastolic function", the term "systolic function" is usually referenced in terms of the left ventricular ejection fraction (LVEF), which is the ratio of stroke volume and end-diastolic volume. [2]
The preferred term is now heart failure with normal ejection fraction (HFNEF) or heart failure with preserved ejection fraction (HFPEF). This is common and is often seen in hypertensive heart disease , hypertrophic cardiomyopathy and aortic stenosis , and may comprise as much as 50% of the total heart failure population. [ 22 ]
Cardiac ventriculography can be performed with a radionuclide in radionuclide ventriculography or with an iodine-based contrast in cardiac chamber catheterization. The 3 major measurements obtained by cardiac ventriculography are: Ejection Fraction; Stroke Volume; Cardiac Output