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Cardiotoxicity is the occurrence of heart dysfunction as electric or muscle damage, resulting in heart toxicity. [1] This can cause heart failure, arrhythmia, myocarditis, and cardiomyopathy in patients. [2] Some effects are reversible, while in others, permanent damage requiring further treatment may arise. The heart becomes weaker and is not ...
Two well known anticancer drug families that cause cardiotoxicity are anthracyclines and monoclonal antibodies targeting HER2. Other types of anticancer drugs that can lead to cardiotoxicity include alkylating agents such as cyclophosphamide, BCR-ABL1 targeting receptor tyrosine kinases such as imatinib, and VEGF antibodies such as bevicizumab. [5]
Lung symptoms in a patient who is taking a medicinal drug that can cause pulmonary toxicity should not automatically lead to a diagnosis of "pulmonary toxicity due to the medicinal drug", because some patients can have another (i.e., simultaneous) lung disease, e.g. an infection of the lungs not related to the medicinal drugs the patient is ...
Pulmonary heart disease, also known as cor pulmonale, is the enlargement and failure of the right ventricle of the heart as a response to increased vascular resistance (such as from pulmonic stenosis) or high blood pressure in the lungs. [2] Chronic pulmonary heart disease usually results in right ventricular hypertrophy (RVH), [4] whereas ...
If taken during pregnancy or breastfeeding it can cause problems in the fetus or the infant. [4] It is a class III antiarrhythmic medication. [4] It works partly by increasing the time before a heart cell can contract again. [4] [6] Amiodarone was first made in 1961 and came into medical use in 1962 for chest pain believed to be related to the ...
Heart murmurs may indicate the presence of valvular heart disease, either as a cause (e.g., aortic stenosis) or as a consequence (e.g., mitral regurgitation) of heart failure. [32] Reverse insufficiency of the left ventricle causes congestion in the blood vessels of the lungs so that symptoms are predominantly respiratory. Reverse insufficiency ...
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