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Ceftriaxone and azithromycin are each used to combat numerous other infections; and the more they are used, the more opportunity gonorrhea has to develop resistance to them.
Gonorrhea is the second-most common sexually transmitted infection (STI) in the U.S. There were nearly 650,000 cases of gonorrhea reported in 2022, ... ceftriaxone and azithromycin, is a “global ...
Asthma exacerbations can be caused by chronic neutrophilic inflammation, and azithromycin is known to reduce this type of inflammation due to its immunomodulatory properties. The recommended dosage for controlling asthma exacerbations with azithromycin is either 500 mg or 250 mg taken orally as tablets three times a week.
Gonorrhea if left untreated may last for weeks or months with higher risks of complications. [19] One of the complications of gonorrhea is systemic dissemination resulting in skin pustules or petechia, septic arthritis, meningitis, or endocarditis. [19] This occurs in between 0.6 and 3% of infected women and 0.4 and 0.7% of infected men. [19]
As of 2010, the recommended treatment is a single 250 mg intramuscular injection of ceftriaxone, sometimes in combination with azithromycin or doxycycline. [3] [4] However, certain strains of N. gonorrhoeae can be resistant to antibiotics that are normally used to treat it.
Each drug should be administered as a single dose, with the gentamicin entering intramuscularly at a concentration of 240 mg, along with 2 g of azithromycin taken orally. [79] If an individual is not allergic to cephalosporins but ceftriaxone is unavailable, an alternative treatment is a single dose of 800 mg cefixime consumed orally. [79]
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