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Acetylcysteine in a form of a white or white with light yellow cast powder has a pK a of 9.5 at 30 °C. [11] N-acetyl-L-cysteine is soluble in water and alcohol, and practically insoluble in chloroform and ether. [61] Acetylcysteine is highly soluble in water: it dissolves readily in water, forming a clear solution.
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[20] [74] Oral acetylcysteine is given as a 140 mg/kg loading dose followed by 70 mg/kg every four hours for 17 more doses, and if the patient vomits within 1 hour of dose, the dose must be repeated. [75] [76] Oral acetylcysteine may be poorly tolerated due to its unpleasant taste, odor, and its tendency to cause nausea and vomiting. [72]
N-acetylcysteine has been shown to decrease drug-seeking behavior for nicotine and heroin as well. However, N-acetylcysteine does not alter the cocaine-induced rush or euphoria; it only causes a reduction in drug-seeking behavior. N-acetylcysteine works by increasing levels of cysteine in cells, leading to an increase in system Xc- activity.
Thiamphenicol glycinate acetylcysteine (TGA) is a pharmaceutical drug that is a combination of thiamphenicol glycinate ester (TAFGE), which is a derivative of the antibiotic thiamphenicol, and N-acetylcysteine (NAC), which is a mucus-thinning drug. Upon contact with tissue esterases, TGA releases both TAFGE and NAC.
Acetylcysteine, also known as N-acetylcysteine (NAC) Tiopronin This page was last edited on 26 August 2022, at 19:59 (UTC). Text is available under the Creative ...