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Hepatitis B infection has been preventable by vaccination since 1982. [4] [12] As of 2022, the hepatitis B vaccine is between 98% and 100% effective in preventing infection. [1] The vaccine is administered in several doses; after an initial dose, two or three more vaccine doses are required at a later time for full effect. [1]
The WHO elimination target is that less than 2 per cent of babies born to mothers with hepatitis B go on to develop the infection. And data from the UK Health Security Agency (UKHSA) shows the ...
Acute Hepatitis B is a short-term illness that occurs within 6 months of exposure, Chronic Hepatitis B is long term and happens when the virus remains in the body. The younger the child is, the greater their chance of developing a chronic infection and this risk goes down as the child gets older.
Serious side effects from the hepatitis B vaccine are very uncommon. [13] Pain may occur at the site of injection. [13] It is safe for use during pregnancy or while breastfeeding. [13] It has not been linked to Guillain–Barré syndrome. [13] Hepatitis B vaccines are produced with recombinant DNA techniques and contain immunologic adjuvant. [13]
HBsAg (hepatitis B surface antigen) was the first hepatitis B virus protein to be discovered. [15] It consists of small (S), medium (M) and large (L) protein. [16] HBcAg (hepatitis B core antigen) is the main structural protein of HBV icosahedral nucleocapsid and it has function in replication of the virus. [17]
Viral hepatitis is liver inflammation due to a viral infection. [1] [2] It may present in acute form as a recent infection with relatively rapid onset, or in chronic form, typically progressing from a long-lasting asymptomatic condition up to a decompensated hepatic disease and hepatocellular carcinoma (HCC).
Hepatitis D is a defective virus that requires hepatitis B to replicate and is only found with hepatitis B co-infection. [17] In adults, hepatitis B infection is most commonly self-limiting, with less than 5% progressing to chronic state, and 20 to 30% of those chronically infected developing cirrhosis or liver cancer. [ 30 ]
DTwP-HepB-Hib vaccine is a 5-in-1 combination vaccine with five individual vaccines conjugated into one. [1] It protects against diphtheria, tetanus, whooping cough, hepatitis B and Haemophilus influenzae type B, [1] which is generally used in middle- and low-income countries, where polio vaccine is given separately.
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