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  2. Splenomegaly - Wikipedia

    en.wikipedia.org/wiki/Splenomegaly

    Splenomegaly is an enlargement of the spleen. [1] The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen.Splenomegaly is one of the four cardinal signs of hypersplenism which include: some reduction in number of circulating blood cells affecting granulocytes, erythrocytes or platelets in any combination; a compensatory proliferative response in the bone marrow; and the ...

  3. Hepatosplenomegaly - Wikipedia

    en.wikipedia.org/wiki/Hepatosplenomegaly

    Hepatosplenomegaly (commonly abbreviated HSM) is the simultaneous enlargement of both the liver (hepatomegaly) and the spleen (splenomegaly).Hepatosplenomegaly can occur as the result of acute viral hepatitis, infectious mononucleosis, and histoplasmosis or it can be the sign of a serious and life-threatening lysosomal storage disease.

  4. Lymphocytic interstitial pneumonia - Wikipedia

    en.wikipedia.org/wiki/Lymphocytic_interstitial...

    Patients with lymphocytic interstitial pneumonia may present with lymphadenopathy, enlarged liver, enlarged spleen, enlarged salivary gland, thickening and widening of the extremities of the fingers and toes , and breathing symptoms such as shortness of breath and wheezing.

  5. Castell's sign - Wikipedia

    en.wikipedia.org/wiki/Castell's_sign

    To rule out an enlarged spleen, a pretest probability of 30% or less will yield a negative predictive value over 90% (calculation) Given the paucity of physical exam findings to evaluate possible splenomegaly, Castell's sign is the most sensitive, and is thus a good tool to teach in an advanced-type physical diagnosis course.

  6. Tropical splenomegaly syndrome - Wikipedia

    en.wikipedia.org/wiki/Tropical_splenomegaly_syndrome

    The spleen is massively enlarged. It shows dilated sinusoids lined with reticulum cells. There is a marked erythrophagocytosis and lymphocytic infiltration of the pulp. Peripheral smear for malarial parasite is usually negative. Condition may show features of hypersplenism in severe form like anemia and thrombocytopenia.

  7. Felty's syndrome - Wikipedia

    en.wikipedia.org/wiki/Felty's_syndrome

    Splenomegaly is a condition of the spleen causing it to be enlarged. The splenic condition involving Felty syndrome is more specifically noted as inflammatory splenomegaly. The spleen is an important lymphatic organ that is involved in filtration of the blood by discarding old and damaged red blood cells as well as maintaining platelet levels ...

  8. Florida doctor accused of fatally removing wrong organ from ...

    www.aol.com/news/florida-doctor-accused-fatally...

    A Florida doctor who is accused of removing an Alabama man’s liver instead of the spleen, resulting in “immediate and catastrophic death,” had his medical license suspended.. In an emergency ...

  9. Immune thrombocytopenic purpura - Wikipedia

    en.wikipedia.org/wiki/Immune_thrombocytopenic...

    In fact, an enlarged spleen should lead to a search for other possible causes for the thrombocytopenia. Bleeding time is usually prolonged in ITP patients. However, the use of bleeding time in diagnosis is discouraged by the American Society of Hematology practice guidelines [ 15 ] and a normal bleeding time does not exclude a platelet disorder.