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  2. Carcinogenesis - Wikipedia

    en.wikipedia.org/wiki/Carcinogenesis

    However, once a cancer is formed it continues to evolve and to produce sub-clones. It was reported in 2012 that a single renal cancer specimen, sampled in nine different areas, had 40 "ubiquitous" mutations, found in all nine areas, 59 mutations shared by some, but not all nine areas, and 29 "private" mutations only present in one area. [35]

  3. Somatic evolution in cancer - Wikipedia

    en.wikipedia.org/wiki/Somatic_evolution_in_cancer

    In whole genome sequencing of different types of cancers, large numbers of mutations were found in two breast cancers (about 20,000 point mutations [43]), 25 melanomas (9,000 to 333,000 point mutations [44]) and a lung cancer (50,000 point mutations and 54,000 small additions and deletions [45]). Genome instability is also referred to as an ...

  4. Causes of cancer - Wikipedia

    en.wikipedia.org/wiki/Causes_of_cancer

    A cancer syndrome or family cancer syndrome is a genetic disorder in which inherited genetic mutations in one or more genes predisposes the affected individuals to the development of cancers and may also cause the early onset of these cancers. Although cancer syndromes exhibit an increased risk of cancer, the risk varies.

  5. New breast cancer genes found in women of African ancestry ...

    www.aol.com/news/breast-cancer-genes-found-women...

    The American Cancer Society says many genetic mutations previously identified as breast cancer risk factors in white women are also strongly linked with disease risk in Black women, and advises ...

  6. Oncogene - Wikipedia

    en.wikipedia.org/wiki/Oncogene

    If, through mutation, normal genes promoting cellular growth are up-regulated (gain-of-function mutation), they predispose the cell to cancer and are termed oncogenes. Usually, multiple oncogenes, along with mutated apoptotic or tumor suppressor genes, act in concert to cause cancer. Since the 1970s, dozens of oncogenes have been identified in ...

  7. Cancer - Wikipedia

    en.wikipedia.org/wiki/Cancer

    Ulceration can cause bleeding that can lead to symptoms such as coughing up blood (lung cancer), anemia or rectal bleeding (colon cancer), blood in the urine (bladder cancer), or abnormal vaginal bleeding (endometrial or cervical cancer). Although localized pain may occur in advanced cancer, the initial tumor is usually painless.

  8. This Breast Cancer Surgeon Discovered Her Own Cancer At ... - AOL

    www.aol.com/breast-cancer-surgeon-discovered-her...

    That said, many physicians and some large foundations, like the National Breast Cancer Foundation, recommend that all people with breasts—regardless of their cancer risk—perform breast self ...

  9. Mutagen - Wikipedia

    en.wikipedia.org/wiki/Mutagen

    Other carcinogens may cause cancer through a variety of mechanisms without producing mutations, such as tumour promotion, immunosuppression that reduces the ability to fight cancer cells or pathogens that can cause cancer, disruption of the endocrine system (e.g. in breast cancer), tissue-specific toxicity, and inflammation (e.g. in colorectal ...