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Currently, in the United States, phages are used for treating bacterial infections only when patients have multi-drug resistant (MDR) life-threatening infections, or when patients are immunocompromised and antibiotic therapy is not a viable option.
With lytic phages such as the T4 phage, bacterial cells are broken open (lysed) and destroyed after immediate replication of the virion. As soon as the cell is destroyed, the phage progeny can find new hosts to infect. [13] Lytic phages are more suitable for phage therapy. Some lytic phages undergo a phenomenon known as lysis inhibition, where ...
Plaque exhibiting bacterial lawn with clearings made by Artharobacter phage GantcherGoblin.. The Actinobacteriophage database, more commonly known as PhagesDB, is an interactive, comprehensive, database-backed website that collects and shares information related to the discovery, characterization and genomics of viruses that typically infect Actinobacterial hosts.
Even engineered phages and induced artificial internalization of phages into mammalian cells do not result in phage propagation. [115] Natural transcytosis of unmodified phages, that is, uptake and internal transport to the other side of a cell, which was observed in human epithelial cells, did not result in phage propagation or cell damage. [116]
[8] [9] The molecular structure of Ff phages was determined using a number of physical techniques, especially X-ray fiber diffraction, [2] [6] solid-state NMR and cryo-electron microscopy. [10] The structures of the phage capsid and of some other phage proteins are available from the Protein Data Bank. [6]
Mycobacteriophage Bxb1 Structure [1]. A mycobacteriophage is a member of a group of bacteriophages known to have mycobacteria as host bacterial species. While originally isolated from the bacterial species Mycobacterium smegmatis and Mycobacterium tuberculosis, [2] the causative agent of tuberculosis, more than 4,200 mycobacteriophage species have since been isolated from various environmental ...
The issue of using Ff phages for phage display is that they require the protein of interest to be translocated across the bacterial inner membrane before they are assembled into the phage. [46] Some proteins cannot undergo this process and therefore cannot be displayed on the surface of Ff phages. In these cases, T7 phage display is used ...
Filamentous phages retard bacterial growth but, contrasting with the lambda phage and the T7 phage, are not generally lytic. Helper phages are usually engineered to package less efficiently (via a defective phage origin of replication) [ 5 ] than the phagemid so that the resultant phage particles contain predominantly phagemid DNA.