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Plaque exhibiting bacterial lawn with clearings made by Artharobacter phage GantcherGoblin.. The Actinobacteriophage database, more commonly known as PhagesDB, is an interactive, comprehensive, database-backed website that collects and shares information related to the discovery, characterization and genomics of viruses that typically infect Actinobacterial hosts.
With lytic phages such as the T4 phage, bacterial cells are broken open (lysed) and destroyed after immediate replication of the virion. As soon as the cell is destroyed, the phage progeny can find new hosts to infect. [13] Lytic phages are more suitable for phage therapy. Some lytic phages undergo a phenomenon known as lysis inhibition, where ...
Phages make up the majority of most viromes and are currently understood as being the most abundant organism. [5] Oftentimes scientists will look only at a phageome instead of a virome while conducting research. Variations due to many factors have also been explored such as diet, age, and geography.
Phage typing is a phenotypic method that uses bacteriophages ("phages" for short) for detecting and identifying single strains of bacteria. [1] Phages are viruses that infect bacteria and may lead to bacterial cell lysis. [2] The bacterial strain is assigned a type based on its lysis pattern. [3]
Characteristics given are cluster assignment, number of subclusters (Sub.), number of phages in the cluster, host species from which the phages were isolated, the average genome size, average percent GC content, average number of ORFS, and the morphotype. Species abbreviations are Bacillus anthracis (A), Bacillus cereus (C), Bacillus sp.
Phages fd, f1, M13 and other related phages are Ff phages, for F specific (they infect Escherichia coli carrying the F-episome) filamentous phages, using the concept of vernacular name. [45] Filamentous bacteriophage engineered to display immunogenic peptides are useful in immunology and wider biological applications.
Dating back to the 1940s and continuing today, T-even phages are considered the best studied model organisms. Model organisms are usually required to be simple with as few as five genes. Yet, T-even phages are in fact among the largest and highest complexity virus, in which these phage's genetic information is made up of around 300 genes.
Even engineered phages and induced artificial internalization of phages into mammalian cells do not result in phage propagation. [115] Natural transcytosis of unmodified phages, that is, uptake and internal transport to the other side of a cell, which was observed in human epithelial cells, did not result in phage propagation or cell damage. [116]