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Alpha blockers, also known as α-blockers or α-adrenoreceptor antagonists, are a class of pharmacological agents that act as antagonists on α-adrenergic receptors (α-adrenoceptors). [2] Historically, alpha-blockers were used as a tool for pharmacologic research to develop a greater understanding of the autonomic nervous system.
Tamsulosin is an alpha blocker and works by relaxing muscles in the prostate. [10] Specifically it is an α 1-adrenergic receptor blocker. [6] Tamsulosin was approved for medical use in the United States in 1997. [6] It is available as a generic medication. [9]
It was the first alpha blocker which was used for treating Benign Prostatic Hyperplasia. [22] Another Alpha Blocker Prazosin, which was the first drug selective to alpha 1 receptor, was developed in 1987 [22] for the therapy of Benign Prostatic Hyperplasia. Other alpha blockers are then introduced for several diseases. [22]
The second group contains the alpha (α) adrenoreceptors. There are only α 1 and α 2 receptors. Adrenergic receptors are located near the heart, kidneys, lungs, and gastrointestinal tract. [1] There are also α-adreno receptors that are located on vascular smooth muscle. [2] Antagonists reduce or block the signals of agonists.
Alpha-1 blocker, blocks alpha receptors and it relaxes the smooth muscles in the bladder. It helps the urine to flow smoothly and it can lessen the pain caused by the bladder pressing on the prostate. [44] [45] Selective alpha-1 blockers are better tolerated than non-selective alpha blockers in the body and therefore works better on BPH. [2]
Alpha 1 blockers cause vasodilation by relaxing smooth muscles that control blood vessel diameter, leading to lower blood pressure. [1] FDA-approved uses of these drugs include treating conditions like benign prostatic hyperplasia, hypertension, pheochromocytoma, extravasation management, and reversal of local anesthesia.
Alpha-1 blockers (108 P) Alpha-2 blockers (1 C, 67 P) Pages in category "Alpha blockers" The following 14 pages are in this category, out of 14 total.
6 Mixed alpha + beta blockers. 7 Calcium channel blockers. 8 Antimineralocorticoid. 9 Antiplatelet drug. 10 Anticoagulant. 11 Fibrinolytics. 12 Diuretics. 13 References.