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Microcytic anaemia; Microcytosis is the presence of red cells that are smaller than normal. Normal adult red cell has a diameter of 7.2 µm. Microcytes are common seen in with hypochromia in iron-deficiency anaemia, thalassaemia trait, congenital sideroblastic anaemia and sometimes in anaemia of chronic diseases.
A blood smear showing hypochromic (and microcytic) anemia. Note the increased central pallor of the red blood cells. Hypochromic anemia is a generic term for any type of anemia in which the red blood cells are paler than normal. (Hypo- refers to less, and chromic means colour.) A normal red blood cell has a biconcave disk shape and will have an ...
Microcytic anemia is not caused by reduced DNA synthesis [citation needed].. Thalassemia can cause microcytosis. Depending upon how the terms are being defined, thalassemia can be considered a cause of microcytic anemia, or it can be considered a cause of microcytosis but not a cause of microcytic anemia.
Based on 2005-2006 estimates, the Centers for Disease Control and Prevention has stated that approximately 5.5 million Americans a year are either admitted to a hospital or seen by a physician, with some form of anemia as their primary diagnosis. [4] Symptoms of anaemia include Plummer–Vinson syndrome, candidal infections.
The most common causes of microcytic anemia are iron deficiency (due to inadequate dietary intake, gastrointestinal blood loss, or menstrual blood loss), thalassemia, sideroblastic anemia or chronic disease. In iron deficiency anemia (microcytic anemia), it can be as low as 60 to 70 femtolitres
Neurologic symptoms of depression, somnolence, confusion, and neuropathy (due to impaired sphingosine synthesis) and microcytic anemia [27] [28] Uncommon, although it may be observed in certain conditions, such as end-stage kidney diseases or malabsorption syndromes , such as celiac disease , Crohn disease or ulcerative colitis .