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The spleen has a unique location, embryological development and histological structure that differs significantly from other lymphoid organs. Special histological features define several important functions of the spleen, such as filtering blood, maintaining immune response balance and recycling iron.
The spleen is an encapsulated organ that filters blood and immunologically monitors blood. Capsule - dense connective tissue enclosing the organ. Trabeculae - connective tissue that extends inward from the capsule through which blood vessels enter the pulp.
The spleen is an essential part of the immune system, which is also responsible for filtering blood and removing damaged or old red blood cells. At a gross level, the spleen's parenchyma consists of red pulp, with small white nodules of lymphatic tissue scattered throughout called the white pulp.
The spleen derives from a mass of mesenchymal cells in the dorsal mesogastrium, later known as the greater omentum. Vasculature of the primordial spleen begins to develop in the fifth week when hematogenesis (blood cell formation) first develops along the aorta and parts of the mesenchyme.
This review will focus on cell types, cell organization and immunologic functions specific to the spleen, and how these impact initiation of adaptive immunity to systemic blood-borne antigens. Potential differences in structure and function between murine and human spleen will also be discussed.
The spleen is the largest secondary immune organ in the body and is responsible for initiating immune reactions to blood-borne antigens and for filtering the blood of foreign material and old or damaged red blood cells.
The spleen is a soft, somewhat fragile organ surrounded by a flexible connective tissue capsule comprised of collagen and elastic fibers. As in lymph nodes, some connective tissue extends from the outer capsule into the interior of the spleen forming partial septa known as trabeculae.
The spleen combines the innate and adaptive immune system in a uniquely organized way. The structure of the spleen enables it to remove older erythrocytes from the circulation and leads to the...
The spleen is the largest organ of your lymphatic system, a subdivision of the immune system. Its network of trabeculae, blood vessels and lymphoid tissue provides an environment in which white blood cells ( lymphocytes ) proliferate while old damaged red blood cells (erythrocytes) are recycled.
The spleen is the largest secondary immune organ in the body and is responsible for initiating immune reactions to blood-borne antigens and for filtering the blood of foreign material and old or damaged red blood cells.