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Sodium methylparaben (sodium methyl para-hydroxybenzoate) is a compound with formula Na(CH 3 (C 6 H 4 COO)O). [1] It is the sodium salt of methylparaben. [1] It is a food additive with the E number E219 which is used as a preservative. [2]
Soil adsorption coefficient values were calculated by the U.S. Environmental Protection Agency as 1.94 (methylparaben), 2.20 (ethylparaben), 2.46 (propylparaben), and 2.72 (butylparaben), [28] all of which suggest that parabens have the ability to adhere to the organic portion of sediment and sludge, and thus, persist environmentally. [29]
Methylparaben is commonly used as a fungicide in Drosophila food media at 0.1%. [5] To Drosophila , methylparaben is toxic at higher concentrations, has an estrogenic effect (mimicking estrogen in rats and having anti- androgenic activity), and slows the growth rate in the larval and pupal stages at 0.2%.
A new opioid-free pain medication was approved by the U.S. Food and Drug Administration (FDA) on Thursday, marking a non-addictive alternative for patients. Journavx (suzetrigine), made by Vertex ...
A 2018 pooled analysis from three phase III, randomized, double-blind, placebo-controlled studies on usage for Opioid-Induced Constipation, found that the numbers of patients reporting adverse effects were similar in both the lubiprostone and placebo treatment groups for all opioid classes (P ≥ 0.125); however, gastrointestinal adverse ...
Side effects from using ear drops used to remove ear wax are uncommon, but may result in discomfort, irritation, or pain. [5] Antibiotic ear drops may cause ear discomfort, pain, or itching. [ 1 ] When cold ear drops are used, it may cause brief but severe dizziness and/or vertigo.
Valproic acid, and its derivatives such as sodium valproate and divalproex sodium, causes cognitive deficit in the child, with an increased dose causing decreased intelligence quotient and use is associated with adverse neurodevelopmental outcomes (cognitive and behavioral) in children.
A study into the effects of the benzodiazepine receptor antagonist, flumazenil, on benzodiazepine withdrawal symptoms persisting after withdrawal was carried out by Lader and Morton. Study subjects had been benzodiazepine-free for between one month and five years, but all reported persisting withdrawal effects to varying degrees.