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Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. [ 5 ] [ 6 ] [ 7 ] It achieves this by inhibiting Ca 2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors . [ 8 ]
When used in a vein, onset of action is generally within one minute and effects last for up to 10 minutes. [7] Common side effects include low blood pressure, increased saliva production, muscle pain, and rash. [7] Serious side effects include malignant hyperthermia, hyperkalemia and allergic reactions.
Medical treatments include baclofen, diazepam and dantrolene which is a muscle-relaxant. Dantrolene has many side effects and as such, it is usually not the first choice in treatment of spasticity. The side effects include dizziness, nausea and weakness. [13]
Bacterial meningitis, for instance, "requires immediate intravenous antibiotics and sometimes corticosteroids to reduce inflammation, while viral meningitis usually resolves on its own with rest ...
While some added sugar can be part of a balanced diet, consuming excess amounts of added sugar has been linked with negative effects on gut health and insulin resistance, both of which can ...
Neuroleptic malignant syndrome (NMS) is a rare [5] [6] but life-threatening reaction that can occur in response to antipsychotics (neuroleptic) or other drugs that block the effects of dopamine. [ 1 ] [ 7 ] Symptoms include high fever , confusion, rigid muscles, variable blood pressure, sweating, and fast heart rate. [ 1 ]
The debate over whether people ages 60 and up should take aspirin continues as medical experts learn more about the potential pros and cons of long-term use.. Aspirin is an over-the-counter ...
Dantrolene sodium, the only available medical treatment for malignant hyperthermia. The current treatment of choice is the intravenous administration of dantrolene, the only known antidote, discontinuation of triggering agents, and supportive therapy directed at correcting hyperthermia, acidosis, and organ dysfunction. Treatment must be ...