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para-Methoxyamphetamine (PMA), also known as 4-methoxyamphetamine (4-MA), is a designer drug of the amphetamine class with serotonergic effects. [2] [3] [4] Unlike other similar drugs of this family, PMA does not produce stimulant, euphoriant, or entactogen effects, [5] and behaves more like an antidepressant in comparison, [6] though it does have some psychedelic properties.
In addition to its MRA activity, PMMA is a potent monoamine oxidase A (MAO-A) inhibitor. [8] Its IC 50 Tooltip half-maximal inhibitory concentration for MAO-A inhibition has been reported to be 1,700 nM. [8] This is several-fold less potent than the related agents para-methoxyamphetamine (PMA) and 4-methylthioamphetamine (4-MTA). [8]
para-Methoxy ethyl amphetamine (PMEA), is a stimulant drug related to PMA. PMEA reputedly produces similar effects to PMA, but is considerably less potent [1] and seems to have slightly less tendency to produce severe hyperthermia, at least at low doses. At higher doses however the side effects and danger of death approach those of PMA itself ...
1-10 minutes, or up to 18 hours Visual disturbance, eye pain, pinpointing of the pupils, runny nose, chest tightness, breathing difficulty, cough, severe nasal congestion, nausea, diarrhea, vomiting, and twitching, VX Gas: colorless Odor: none 1-10 minutes, or up to 42 hours Constricted pupils, visual disturbance, eye pain, runny nose,
In vitro, 4-methylamphetamine acts as a potent and well-balanced serotonin, norepinephrine, and dopamine releasing agent (SNDRA) with EC 50 Tooltip half-maximal effective concentration values of 53.4 nM, 22.2 nM, and 44.1 nM at the serotonin, norepinephrine, and dopamine transporters, respectively.
Fentanyl is a synthetic opioid about 50 times more powerful than heroin and 100 times more powerful than morphine. Opioids accounted for about 82,000 U.S. deaths in 2022, ten times the number in ...
February 2, 2025 at 8:00 PM Newsweek’s profile of a former death row inmate and convicted murderer , who is transitioning into a woman, shocked readers who called it "puff piece."
3-Methoxyamphetamine (3-MA), also known as meta-methoxyamphetamine (MMA), is a monoamine releasing agent (MRA) of the amphetamine family. [2] [3] [4] It is a positional isomer of para-methoxyamphetamine (PMA; 4-methoxyamphetamine). [1] [5] 3-MA has similar effects in animal drug discrimination tests to PMA. [2]