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para-Methoxyamphetamine (PMA), also known as 4-methoxyamphetamine (4-MA), is a designer drug of the amphetamine class with serotonergic effects. [2] [3] [4] Unlike other similar drugs of this family, PMA does not produce stimulant, euphoriant, or entactogen effects, [5] and behaves more like an antidepressant in comparison, [6] though it does have some psychedelic properties.
In addition to its MRA activity, PMMA is a potent monoamine oxidase A (MAO-A) inhibitor. [8] Its IC 50 Tooltip half-maximal inhibitory concentration for MAO-A inhibition has been reported to be 1,700 nM. [8] This is several-fold less potent than the related agents para-methoxyamphetamine (PMA) and 4-methylthioamphetamine (4-MTA). [8]
para-Methoxy ethyl amphetamine (PMEA), is a stimulant drug related to PMA. PMEA reputedly produces similar effects to PMA, but is considerably less potent [1] and seems to have slightly less tendency to produce severe hyperthermia, at least at low doses. At higher doses however the side effects and danger of death approach those of PMA itself ...
Substituted amphetamines, or simply amphetamines, are a class of compounds based upon the amphetamine structure; [1] it includes all derivative compounds which are formed by replacing, or substituting, one or more hydrogen atoms in the amphetamine core structure with substituents.
It’s just after 5 a.m. on a Monday in November. Fischer, a 31-year-old construction worker, has to get from his home on the outskirts of Rapid City, South Dakota, to Fort Collins, Colorado — some 350 miles away — and he has to get there by noon. He’s wearing a Kangol hat, jeans, a T-shirt and, for warmth, a hoodie and a jacket.
Fentanyl is a synthetic opioid about 50 times more powerful than heroin and 100 times more powerful than morphine. Opioids accounted for about 82,000 U.S. deaths in 2022, ten times the number in ...
para-Methoxyamphetamine (PMA or "Dr. Death", a drug that causes so much overheating that it can kill within 40 minutes) is sometimes sold as ecstasy. [ citation needed ] There is one published case [ 47 ] of an ecstasy tablet being adulterated with 8 mg of strychnine , a toxic alkaloid which was used in very low doses (less than 1 mg) as a ...
ALAMO, N.M. (Reuters) - - Twenty-eight-year old Ambrose Begay died after a fentanyl overdose under a tree 125 yards from his home on the Alamo Navajo reservation in southern New Mexico two years ago.