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Familial atrial fibrillation is an autosomal dominant heart condition that causes disruptions in the heart's normal rhythm. [ 1 ] [ 2 ] This condition is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria ), which causes the heartbeat to become fast and irregular.
Atrial fibrillation is associated with an increased risk of heart failure, dementia, and stroke. [3] [12] It is a type of supraventricular tachycardia. [14] Atrial fibrillation frequently results from bursts of tachycardia that originate in muscle bundles extending from the atrium to the pulmonary veins. [15]
ARCA has identified common genetic variations that it believes predict individual patient response to Gencaro, giving it the potential to be the first genetically-targeted atrial fibrillation ...
For example, a meta-analysis accomplished in 2018 revealed the discovery of 70 new loci associated with atrial fibrillation. It has been identified different variants associated with transcription factor coding-genes, such as TBX3 and TBX5 , NKX2-5 o PITX2 , which are involved in cardiac conduction regulation, in ionic channel modulation and ...
Gencaro TM Cardiovascular Effect on Patients with Atrial Fibrillation Paper Published in European Journal of Heart Failure BROOMFIELD, Colo.--(BUSINESS WIRE)-- ARCA biopharma, Inc. (NAS: ABIO ...
Those affected by arrhythmogenic cardiomyopathy may not have any symptoms at all despite having significant abnormalities in the structure of their hearts. [6] If symptoms do occur, the initial presentation is often due to abnormal heart rhythms (arrhythmias) which in arrhythmogenic cardiomyopathy may take the form of palpitations, or blackouts. [7]
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited genetic disorder that predisposes those affected to potentially life-threatening abnormal heart rhythms or arrhythmias. The arrhythmias seen in CPVT typically occur during exercise or at times of emotional stress, and classically take the form of bidirectional ...
Unlike the situation in AL amyloidosis, the ECG voltage is often normal, although low voltage may be seen (despite increased wall thickness on echocardiography). Marked axis deviation, bundle branch block, and AV block are common, as is atrial fibrillation. [citation needed]